Saturation Genome Editing

Per-variant endogenous-locus function scores (MaveDB SGE studies). The leaderboard metric is AUPRC for the ClinGen/ExCALIBR calibrated_class abnormal-vs-normal call — computed per accession (study) then macro-averaged over consequence subsets and accessions (scores are non-comparable across studies). Higher = better; the abnormal base rate varies per gene/subset (~5–16%).

Dataset

Leaderboard

AUPRC ×100, colored on the 0→100 scale below (anchored at 0, the metric's full range — abnormal base rate ~5–16% varies per gene). Macro = mean of the missense + splicing subsets; Both = the two pooled. Column sub-labels: positives vs. negatives for a selected gene, or genes-averaged for the all-genes macro. Click a column header to sort. Hover a model for its card; hover a cell for ± SE.